Overview:

USP20 (ubiquitin carboxyl-terminal hydrolase 20) is a cysteine protease deubiquitinating enzyme belonging to the ubiquitin-specific protease (USP) family and deubiquitinates several proteins such as thyronine deiodinase type 2 (D2), Hypoxia-inducible factor 1α (HIF1α), and β2 adrenergic receptor. It is involved in ADRB2 recycling and resensitization, regulating thyroid hormone regulation and stabilizing and enhancing HIF1A (1). USP20 was also identified to be a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex, as it is involved in the ubiquitination and degradation of HIF1α subunits (2).

Gene Aliases:

LSFR3A, HVDU2, VDU2, KIAA1003

Genbank Number:

NM_006676

References:

1. Berthouze, M. et al: The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. EMBO J. 28: 1684-1696, 2009.

2. Zaibo, L. et al: Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel–Lindau tumor suppressor. Biochemical and Biophysical Research Communications 294, (3): 700-709, 2002.