Overview:

USP7 (ubiquitin carboxyl-terminal hydrolase 7) belongs to the peptidase C19 family and deubiquitinates FOXO4, p53, MDM2, and WASH proteins, and regulates their activities through counteracting ubiquitin ligase activity of proteins such as HDM2 and TRIM27. USP7 was found to contribute to the stabilization and trans-activation of herpesvirus 1 transcriptional protein by strongly interacting with ICP0, a regulatory protein that stimulates lytic infection and the reactivation of viral genome (1). High expression of USP7 was correlated with the proliferation, migration and invasion capacities of hepatocellular carcinoma, indicating that the enzyme may play a role in promoting tumour progression (2).

Gene Aliases:

HAUSP, TEF1

Genbank Number:

NM_003470

References:

1. Boutell, C. et al: Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7. Journal of virology 79(19), 12342-54, 2005.

2. Wang, X. et al: Clinical Significance of Ubiquitin Specific Protease 7 (USP7) in Predicting Prognosis of Hepatocellular Carcinoma and its Functional Mechanisms. Medical science monitor:international medical journal of experimental and clinical research 24: 1742-1750, 2018