Overview:

USP5 (ubiquitin carboxyl-terminal hydrolase 5) is a member of the ubiquitin-specific protease family of deubiquitinating enzymes (DUBs) and is involved in many processes including maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism at the proximal end of the chain. Increased USP5 has been associated with tumour formation and progression of pancreatic cancer due to its role in FoxM1 protein stabilization (1). USP5 is also involved in the upregulation of Notch signaling and downregulation of receptor tyrosine kinase signaling in Drosophila eye development through the deubiquitination of unanchored polyubiquitin (2).

Gene Aliases:

ISOT, Isopeptidase T

Genbank Number:

NM_003481

References:

1. Li, X.Y. et al: USP5 promotes tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein. Biochem. Biophys. Res. Commun. 492:48-54, 2017.

2. Ling, X. et al: The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development. FEBS 591(6): 875-888, 2017.