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Recombinant tag-free human Tau K18 (P61L) Protein Monomer was expressed in E. coli cells.
Catalog No. T18-57GN
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
T18-57GN-100 | 100 ug | $455 | |
T18-57GN-200 | 200 ug | $755 | |
T18-57GN-500 | 500 ug | $1455 | |
T18-57GN-BULK | BULK | Contact Us |
Overview:
Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).
Genbank Number:
References:
1. www.alz.org/alzheimers-dementia/facts-figures
2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907)
3. Matsumoto, G. et al. (2018). Int J Mol Sci. 19, 1497.
4. Goedert, M. and Spillantini, M. G. (2017). Mol Brain. 10:18.
5. Guo, J. and Lee, M.Y. (2013). FEBS Lett. 587(6): 717-723.
6. Alberici, A. et al. (2004). J Neurol Neurosurg Psychiatry. 75:1607-1610.
Alternative Names:
Microtubule-associated protein tau; MAPT; MAP; Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Isoform 4
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
SDS-PAGE of ~16 kDa Human Tau Protein K18 (P61L) Monomer (Cat# T18-57GN). Lane 1: MW Ladder. Lane 2: Tau Protein Monomer (Cat# T18-57GN).
There are no related publications available for this product.
Neurobiology
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