Overview:

MARK1 is a member of the MARK family and is a serine/threonine-protein kinase that plays a key role in signal transduction. Due to its protein serine/threonine kinase activity, MARK1 is known to mediate phosphorylation of key proteins involved in signal transduction and cell communication. MARK1 phosphorylates microtubule-associated proteins and trigger microtubule disruption (1). Gene mutation studies performed in mice revealed that after targeted disruption of the MARK1 gene, the mice lacked the ability to drink, and displayed hind leg motor dysfunction (2).

Gene Aliases:

MARK, KIAA1477

Genbank Number:

BC114478

References:

1. Drewes, G. et al: MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 1997; 89:297-308.
2. Manabu, N. et al: A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. The FASEB Journal. 2006; 20:1718-1720.