Rabbit Polyclonal Antibody
Catalog No. H84-65R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
H84-65R-100 | 100 ug | $325 | |
H84-65R-BULK | BULK | Contact Us |
Overview:
HDAC2 or Histone deacetylase 2 belongs to the histone deacetylase family that acts via the formation of large multiprotein complexes, and is responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). HDAC2 forms transcriptional repressor complexes by associating with many different proteins and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDAC2 functions in modulating synaptic plasticity and long-lasting changes of neural circuits, which in turn negatively regulates learning and memory (1). HDAC1 and HDAC2 are functionally redundant in cardiac growth and development and they maintain cardiomyocyte identity and function (2).
References:
1. Guan, J.S. et.al: HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459: 55-60, 2009.
2. Montgomery, R. L. et.al: Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev. 21: 1790-1802, 2007.
Specificity:
Recognizes the HDAC2 protein phosphorylated at serine 394
Cross Reactivity:
Human, Mouse and Rat
Host / Isotype / Clone#:
Rabbit, IgG
Immunogen:
Phosphopeptide derived from human HDAC2 around the phosphorylation site of serine 394 (E-D-SP-G-D).
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Anti-phospho-HDAC2 (Ser394).
Sample Data:
Western blot analysis of extracts from HT-29 cells untreated or treated with UV (20 mins), using HDAC2 antibody and Anti-phospho-HDAC2 (Ser394) (Lane 3 and 4)
Duan Wenwen et al., Design, Synthesis and Antitumor Evaluation of Novel Histone Deacetylase (HDAC) Inhibitors Equipped with Phenylsulfonylfuroxan Module as Nitric Oxide (NO) Donor Journal of Medicinal Chemistry May 2015 10.1021/acs.jmedchem.5b00317
Hou Xuben et al., Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8 Journal of Chemical Information and Modeling March 2015 10.1021/ci500762z
Cardiovascular Disease, WNT Signaling
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