Recombinant full-length human TRIB1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T30-30G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
T30-30G-20 | 20 ug | $215 | |
T30-30G-50 | 50 ug | $435 | |
T30-30G-BULK | BULK | Contact Us |
Overview:
TRIB1 or tribbles homolog 1 protein encodes one of three members of the Tribbles family that share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. TRIB1 is highly expressed in skeletal muscle, thyroid, pancreas, peripheral blood leukocytes, and bone marrow. The overexpression of TRIB1 may be functionally important consequence of 8q24 amplicons in AML and MDS (1). TRIB1 is a p65-interacting negative regulator of NF-kappa-B-dependent transcription (2).
Gene Aliases:
C8FW; GIG2; SKIP1; TRB1
Genbank Number:
References:
1. Storlazzi, C. T.et.al: Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies. Hum. Molec. Genet. 13: 1479-1485, 2004.
2. Wu, M. et.al: SINK is a p65-interacting negative regulator of NF-kappa-B-dependent transcription. J. Biol. Chem. 278: 27072-27079, 2003.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~70 kDa
There are no related publications available for this product.
Cancer, Metabolic Disorder
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