Overview:

HER3 is a member of the human epidermal growth factor receptor (EGFR/HER) tyrosine kinase family whose kinase domain lacks several residues critical for catalysis but serves as an activator of the EGFR kinase domain (1,2). Phosphorylation of HER3 by other EGFR family members, most commonly HER2, activates the PI3K/AKT pathway (2). In cancer cells treated with HER2 kinase inhibitors, diminished HER2 activity is compensated for by HER3 overexpression, resulting in tumor cell survival (2).

Genbank Number:

P21860

References:

1. Shi, F. et al: ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. Proc Natl Acad Sci USA 107(17): 7692-7697, 2010.
2. Jura, N. et al: Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc Natl Acad Sci USA 106(51): 21608-21613, 2009.