WWP1 or WW domain containing E3 ubiquitin protein ligase 1 belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes (1). WWP1 are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. WWP1 negatively regulates TGF-beta signaling by directing the degradation of active components of the TGF-beta network. Wwp1 and Ubc18 function to ubiquitinate substrates that regulate longevity induced by diet restriction (2).
AIP5, Tiul1, hSDRP1
1. Flasza, M.et.al: Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. Biochem. Biophys. Res. Commun. 290: 431-437, 2002.
2. Carrano, A.et.al: A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature 460: 396-399, 2009.
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Cancer, Cardiovascular Disease, Cell Cycle