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WWP1 Protein

Recombinant full-length human WWP1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. W296-30G


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Catalog No. Pack Size Price (USD)
W296-30G-20 20 ug $215
W296-30G-50 50 ug $435
W296-30G-BULK BULK Contact Us  


Overview:

WWP1 or WW domain containing E3 ubiquitin protein ligase 1 belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes (1). WWP1 are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. WWP1 negatively regulates TGF-beta signaling by directing the degradation of active components of the TGF-beta network. Wwp1 and Ubc18 function to ubiquitinate substrates that regulate longevity induced by diet restriction (2).


Gene Aliases:

AIP5, Tiul1, hSDRP1


Genbank Number:


References:


1. Flasza, M.et.al: Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. Biochem. Biophys. Res. Commun. 290: 431-437, 2002.

2. Carrano, A.et.al: A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature 460: 396-399, 2009.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~160 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle



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