TRIM32 or tripartite motif containing 32 is a member of the tripartite motif (TRIM) family whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. TRIM32 localizes to cytoplasmic bodies and nucleus, where it interacts with the activation domain of the HIV-1 Tat protein that activates transcription of HIV-1 genes. TRIM32 is a regulator of dysbindin and mutations in TRIM32 may impair substrate ubiquitination (1). Deficiency of TRIM32 may involve both neurogenic and myogenic characteristics (2).
1. Locke, M.et.al: TRIM32 is an E3 ubiquitin ligase for dysbindin. Hum. Molec. Genet. 18: 2344-2358, 2009.
2. Kudryashova, E.et.al: Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component. Hum. Molec. Genet. 18: 1353-1367, 2009.
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Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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