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STUB1 (CHIP) Protein

Recombinant full length human STUB1 (CHIP) was expressed in E. coli cells using an N-terminal His tag.
Catalog No. C268-30H


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Catalog No. Pack Size Price (USD)
C268-30H-20 20 ug $105
C268-30H-50 50 ug $160
C268-30H-BULK BULK Contact Us  


Overview:

CHIP(STUB1) or STIP1 homology and U-box containing protein 1 (also known as E3 ubiquitin protein ligase) is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (1). CHIP acts as a molecular switch for the degradation of misfolded proteins via the proteasome and lysosome pathways (2). CHIP controls the cellular level of BER enzymes and, correspondingly, the efficiency and capacity of BER. CHIP E3 ubiquitin ligases act sequentially in ER membrane and cytosol to monitor the folding status of CFTR and delF508.CHIP possesses intrinsic E3 ubiquitin ligase activity and promotes ubiquitylation.


Gene Aliases:

CHIP; UBOX1; HSPABP2; NY-CO-7; SDCCAG7


Genbank Number:


References:


1. Min, J.-N. et.al: CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control. Molec. Cell. Biol. 28: 4018-4025, 2008.

2. Shin, Y.et.al: The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J. Biol. Chem. 280: 23727-23734, 2005.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~37 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, Metabolic Disorder



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