Home   >    Proteins   >   Ubiquitin Proteins

Parkin Protein

Recombinant full-length human Parkin was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P215-30G


Shop Online



Catalog No. Pack Size Price (USD)
P215-30G-20 20 ug $215
P215-30G-50 50 ug $435
P215-30G-BULK BULK Contact Us  


Overview:

Parkin or parkinson protein 2 is a RING domain-containing E3 ubiquitin protein ligase involved in proteasome-dependent degradation of proteins. Mutations in Parkin can lead to Parkinson’s disease. Parkin is important for mitochondrial quality control by lysosome-dependent degradation of damaged mitochondria through autophagy, or mitophagy (1). Parkin plays an important role in directly supporting mitochondrial function and protecting mitochondrial genomic integrity from oxidative stress (2). Parkin also has essential role in regulating normal respiratory function in mitochondria and in the protection of cells from oxidative stress.


Gene Aliases:

PARK2, AR-JP, PDJ, PRKN, LPRS2


Genbank Number:


References:


1. Yoshii, S. R. et.al: Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J. Biol. Chem. 286: 19630-19640, 2011.

2. Rothfuss, O. et.al: Parkin promotes mitochondrial genome integrity and supports mitochondrial DNA repair. Hum. Molec. Genet. 18: 3832-3850, 2009.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~68 kDa



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology


RELATED PRODUCTS


  PARK7 (DJ-1) Protein, P219-31H


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox