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RNF34L (CARP2), Active

Recombinant full-length human RNF34L was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R297-380G


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Catalog No. Pack Size Price (USD)
R297-380G-20 20 ug $215
R297-380G-50 50 ug $435
R297-380G-BULK BULK Contact Us  


Overview:

E3 ubiquitin-protein ligase RNF34L, also named CARP2 (Caspases-8/10 Associated RING protein 2), acts as RING‑domain E3 ligases, ubiquitinates apical caspases and targets them for proteasome-mediated degradation. CARP gene silencing inhibits tumor cell survival and increases cancer cell sensitivity to the death ligand or chemotherapy-induced apoptosis. CARP proteins target the tumor suppressor p53 for degradation. RNF34L also acts at the level of endocytic vesicles to limit the intensity of TNF-induced NF-κB activation by the regulated elimination of the adaptor protein RIP1.


Gene Aliases:

FRING; CARP2; CARP-2; RNF189; RNF34L; RIFIFYLIN


Genbank Number:


References:


1. Liao, W. et al: CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation. Curr Biol. 18(9):641-649, 2008

2. McDonald, E.R. 3rd et al: Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. PNAS. 20;101(16):6170-6175, 2004 br>
3. Yang, W. et al: CARPs are E3 ligases that target apical caspases and p53. Cancer Biol. Ther. 6(11):1676-1683, 2007


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

73 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Metabolic Disorder, Neurobiology


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