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RNF34 (CARP), Active

Recombinant human RNF34 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R296-380G


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Catalog No. Pack Size Price (USD)
R296-380G-20 20 ug $215
R296-380G-50 50 ug $435
R296-380G-BULK BULK Contact Us  


Overview:

E3 ubiquitin-protein ligase RNF34, also named CARP1 (Caspases-8/10 Associated RING protein 1), acts as RING‑domain E3 ligases, ubiquitinates apical caspases and targets them for proteasome-mediated degradation. CARP gene silencing inhibits tumor cell survival and increases cancer cell sensitivity to the death ligand or chemotherapy-induced apoptosis. CARP proteins target the tumor suppressor p53 for degradation. RNF34 is also a negative regulator of the NOD1 pathway through direct interaction and ubiquitination of NOD1.


Gene Aliases:

RNF34; CARP; CARP1; hRFI; RFI; RIF; RIFF


Genbank Number:


References:


1. Yang, W. et al: CARPs are E3 ligases that target apical caspases and p53. Cancer Biol. Ther. 6(11):1676-1683, 2007

2. McDonald, E.R. 3rd et al: Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. PNAS. 20;101(16):6170-6175, 2004

3. Zhang, R. et al: The E3 Ligase RNF34 is a Novel Negative Regulator of the NOD1 Pathway. Cell Physiol. Biochem. 33:1954-1962, 2014


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

68 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Metabolic Disorder, Neurobiology


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