Home   >    Enzymes   >   Ubiquitin Enzymes

RanBP2, Active

Recombinant human RanBP2 (2553-2838) was expressed in E.coli cells using an N-terminal His tag.
Catalog No. R230-381H


Shop Online



Catalog No. Pack Size Price (USD)
R230-381H-20 20 ug $215
R230-381H-50 50 ug $435
R230-381H-BULK BULK Contact Us  


Overview:

RNA binding protein 2 (RanBP2) acts an E3 SUMO-protein ligase interacting with E2 ligase UBE2I to facilitate SUMO1 and SUMO2 transferring (1). RanBP2 is involved in the modification of nuclear transport by functioning together with the nuclear pore complex through sumoylation (2). Also, RanBP2 is important for the assembly of the PML by sumo conjugation at ‘Lys-490’ (3). In addition, RanBP2 facilitate the modification of HDAC4 (4).


Gene Aliases:

ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2


Genbank Number:


References:


1. Pichler A., et al. The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell, 108:109-120, 2002.

2. Reverter D., et al. Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. Nature, 435:687-692, 2005.

3. Tatham MH, et al. Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. Nat Struct Mol Biol, Jan;12(1):67-74, 2005.

4. Kirsh O., et al. The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J., 21:2682-2691, 2002.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~48 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


RELATED PRODUCTS


  SAE1/UBA2 Complex, Active, U208-380G

  SUMO2 Protein, S294-31H


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox