Overview:

RNA binding protein 2 (RanBP2) acts an E3 SUMO-protein ligase interacting with E2 ligase UBE2I to facilitate SUMO1 and SUMO2 transferring (1). RanBP2 is involved in the modification of nuclear transport by functioning together with the nuclear pore complex through sumoylation (2). Also, RanBP2 is important for the assembly of the PML by sumo conjugation at ‘Lys-490’ (3). In addition, RanBP2 facilitate the modification of HDAC4 (4).

Gene Aliases:

ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2

Genbank Number:

NM_006267

References:

1. Pichler A., et al. The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell, 108:109-120, 2002.

2. Reverter D., et al. Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. Nature, 435:687-692, 2005.

3. Tatham MH, et al. Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. Nat Struct Mol Biol, Jan;12(1):67-74, 2005.

4. Kirsh O., et al. The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J., 21:2682-2691, 2002.