MGRN1 or mahogunin ring finger 1, E3 ubiquitin protein ligase is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro (1). MGRN1 gene encodes 4 mRNA isoforms that contain a central C3HC4 RING domain as the only recognizable protein motif and regions flanking the RING domain and the N-terminal region of the protein are also conserved between vertebrate and invertebrate genome and MGRN1 is highly expressed in brain (2). MGRN1 has been detected in the adrenal cortex in kidney and its role may relate to the trafficking and/or degradation of the melanocortin 2 receptor.
CD41B, GP2B, ITGA2B, KIAA0544, RNF156
1. Phan, L. K.et.al: The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J. Clin. Invest. 110: 1449-1459, 2002.
2. He, L. et.al: Spongiform degeneration in mahoganoid mutant mice. Science 299: 710-712, 2003.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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