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UBE2F Protein

Recombinant full length human UBE2F was expressed in E. coli cells using an N-terminal His tag.
Catalog No. U220-30H


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Catalog No. Pack Size Price (USD)
U220-30H-20 20 ug $105
U220-30H-50 50 ug $160
U220-30H-BULK BULK Contact Us  


Overview:

UBE2F or ubiquitin-conjugating enzyme E2F is part of the ubiquitin network for protein degradation and is involved in protein neddylation. UBE2F has been shown to function as a NEDD8-conjugating enzyme in vitro and in vivo (1). Covalent attachment of the ubiquitin-like protein NEDD8 to a conserved C-terminal domain (ctd) lysine stimulates Cullin Ring ligase (CRL) ubiquitination activity and prevents binding of the inhibitor CAND1 (2).


Gene Aliases:

NCE2


Genbank Number:


References:

1. Huang, D T. et al: E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell. 2009 Feb 27;33(4):483-95. 2. Boh, B K. et al: Neddylation-induced conformational control regulates cullin RING ligase activity in vivo. J Mol Biol. 2011 Jun 3;409(2):136-45.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~24 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Neurobiology


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