UBE2V2 or ubiquitin-conjugating enzyme E2 variant 2 constitutes a distinct subfamily within the E2 protein family which is critical for the catalytic activity of E2s and also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. UBE2V2 may be involved in the differentiation of monocytes and enterocytes (1). UBE2V2 functions in assembly of novel polyubiquitin chains for DNA repair (2).
DDVit-1; DDVIT1; EDAF-1; EDPF1; MMS2; UEV-2; UEV2
1. Fritsche, J.et.al: Molecular cloning of a 1-alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. Biochem. Biophys. Res. Commun. 235: 407-412, 1997.
2. Hofmann, R. M.et.al: Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96: 645-653, 1999.
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