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JAK3, Active

Recombinant human JAK3 (781-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. J03-11G


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Catalog No. Pack Size Price (USD)
J03-11G-05 5 ug $226
J03-11G-10 10 ug $325
J03-11G-BULK BULK Contact Us  


Overview:

JAK3 is a member of the JAK family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. Low levels of JAK3 expression is detected in immature hematopoietic cells, which dramatically increases during terminal differentiation of these cells suggesting a role of JAK3 in the differentiation of hematopoietic cells. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease) (1). Mice lacking JAK3 show a severe block in B-cell development at the pre-B stage in bone marrow suggesting that JAK3 is critical for the progression of B-cell development in the bone marrow (2).


Gene Aliases:

JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN


Genbank Number:


References:


1.Russell S M, et al: Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 270: 797-799, 1995.

2.Thomis D C, et al: Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270: 794-797, 1995.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~64 kDa



RESEARCH AREAS

Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway


RELATED PRODUCTS


  Anti-JAK2, J02-63R

  Poly (4:1 Glu, Tyr) Peptide, P61-58

  JAK3tide, J03-58

  Ruxolitinib, J01-901


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