Full-length recombinant human TDO2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T213-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| T213-30G-20 | 20 ug | $215 | |
| T213-30G-50 | 50 ug | $435 | |
| T213-30G-BULK | BULK | Contact Us |
Overview:
TDO2 or tryptophan 2, 3-dioxygenase is a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway (1). TDO2 may play a role in cancer and immune biology through the suppression of antitumor immune responses, and single nucleotide polymorphisms in TDO2 may be associated with autism (2).
Gene Aliases:
TDO; TO; TPH2; TRPO
Genbank Number:
References:
1. Comings, D. E. et.al: Localization of human tryptophan oxygenase to 4q31: possible relevance to alcoholism, depression and Tourette syndrome. (Abstract) Am. J. Hum. Genet. 45 (suppl.): A135 only, 1989.
2. Opitz, C. A.et.al: An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478: 197-203,2011.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~69 kDa
There are no related publications available for this product.
Cancer, Metabolic Disorder, Neurobiology
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