Overview:

CyclinH1 is related to the highly conserved cyclin family. Cyclin family members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. CyclinH1 forms a complex with CDK7 kinase and the ring finger protein MAT1 which is able to phosphorylate CDK2 and CDC2 kinases and thus act as a CDK-activating kinase (CAK) (1). Cdk-activating kinase complex is a component of human transcription factor TFIIH and plays an important role in the processes of transcription, DNA repair, and cell cycle progression (2).

Gene Aliases:

CCNH; CAK; p34; p37

Genbank Number:

NM_001239

References:

1. Eki, T. et.al: Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively. Genomics 47: 115-120, 1998.

2. Shiekhattar, R. et.al: Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 374: 283-287, 1995.