Overview:

CCNE2 is belongs to the cyclin family, Cyclin E subfamily. It is encoded by a separate gene from Cyclin E1, but shows substantial amino acid sequence similarity. Like Cyclin E1, it binds and activates the cyclin-dependent kinase 2 (Cdk2), which in turn phosphorylates proteins involved in cell cycle progression such as pRB, p107, NPM1, MCMs, thereby driving cell proliferation. A defect in spermatogenesis is the only phenotype observed in cyclin E2-deficient mice, suggesting its role in male fertility.

Gene Aliases:

CCNE2; CYCE2

Genbank Number:

NM_057749

References:

1. Geng Y, et al. (2003) Cyclin E ablation in the mouse. Cell 114: 431–443.

2. Hwang HC, et al. (2005) Cyclin E in normal and neoplastic cell cycles. Oncogene 24: 2776–2786.

3. Odajima J, et al. (2016). Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo. PLoS Genet. 12(11):e1006429.