Overview:

DNMT1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities (1). DNMT1 enzyme is crucial for stable expression and function in vivo (2). DNMT1 is essential for maintenance of DNA methylation and the interaction of DNMT1 with the replication machinery is not strictly necessary for maintenance of DNA methylation, but improves its efficiency. DNMT1 is necessary and sufficient to maintain global methylation and aberrant CpG island methylation in human cancer cells.

Gene Aliases:

Dnmt; MCMT; Cxxc9; MTase; Met-1; Dnmt1o; m.MmuI; Met1; MommeD2

Genbank Number:

BC053047

References:

1. Yoder, J. A. et.al: New 5-prime regions of the murine and human genes for DNA (cytosine-5)-methyltransferase. J. Biol. Chem. 271: 31092-31097, 1996.

2. Tucker, K. L. et.al: Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene. Proc. Nat. Acad. Sci. 93: 12920-12925, 1996.