Recombinant full-length human BRD3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. B17-30G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
B17-30G-20 | 20 ug | $314 | |
B17-30G-50 | 50 ug | $545 | |
B17-30G-BULK | BULK | Contact Us |
Overview:
As the best characterized binding motif for lysine acetylation, Bromodomains (BRDs) are 110 amino acid highly conserved modules found in transcriptional co-regulators, chromatin modifying enzymes and nuclear scaffold proteins. Initially identified in the protein encoded by the D. melanogaster brahama gene. Along with BRD2, BRD4 and BRDT, Bromodomain-containing protein 3 (BRD3) lacks intrinsic chromatin modifying potential and primarily function as scaffolds for transcription factors or other chromatin regulating factors. It is characterized by the presence of two distinct BRDs at the N-terminal end of the protein. BRD3 is involved in the pathognomonic chromosomal translocations seen in NUT midline carcinoma (NMC).
Gene Aliases:
KIAA0043; ORFX; RING3L
Genbank Number:
References:
1. French CA, et al: BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 63(2):304-7, 2003.
2. Barbieri I, et al: Bromodomains as therapeutic targets in cancer. Brief Funct Genomics. 12(3):219-30, 2013.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
115 kDa
There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cell Cycle, Inflammation, Neurobiology
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