Recombinant full-length human AKT1 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. A16-10H
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AKT1/PKB is a serine/threonine kinase that belongs to the AKT family. AKT1 is activated in cells in response to diverse stimuli such as hormones, growth factors and extracellular matrix components and is involved in glucose metabolism, transcription, survival, cell proliferation, angiogenesis, and cell motility (1). AKT1 is frequently overexpressed and active in many types of human cancers including cancers of colon, breast, brain, pancreas and prostate as well as lymphomas and leukemias (2).
1. Coffer, PJ. et al: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 1998 Oct 1; 335 (Pt 1): 1-13.
2. Anderson, KE. et al: Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol. 1998 Jun 4;8(12): 684-91.
PKB; RAC; PRKBA; MGC99656; RAC-ALPHA
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Sample Activity Data. For specific information on a given lot, see related technical data sheet.
Observed MW ~61 kDa. Calculated MW ~56 kDa.
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Cancer, Cell Cycle