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KDM2A Protein

Recombinant human KDM2A (1-748) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K422-31G


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Catalog No. Pack Size Price (USD)
K422-31G-20 20 ug $215
K422-31G-50 50 ug $435
K422-31G-BULK BULK Contact Us  


Overview:

KDM2A or lysine (K)-specific demethylase 2A is a member of the F-box protein family that are components of the modular E3 ubiquitin protein ligases called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination (1). KDM2A belongs to the Fbls class and, in addition to the presence of an F-box, contains at least six highly degenerated leucine-rich repeats which play a role in epigenetic silencing. The demethylase activity of the JmjC domain-containing proteins is conserved from yeast to human (2).


Gene Aliases:

CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA


Genbank Number:


References:


1. Cenciarelli, C.et.al: Identification of a family of human F-box proteins. Curr. Biol. 9: 1177-1179, 1999.

2. Tsukada, Y. et.al: Histone demethylation by a family of JmjC domain-containing proteins. Nature 439: 811-816, 2006.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~115 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


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