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KDM4B Protein

Recombinant mouse KDM4B (1-725) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K424-31BG


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Catalog No. Pack Size Price (USD)
K424-31BG-20 20 ug $215
K424-31BG-50 50 ug $435
K424-31BG-BULK BULK Contact Us  


Overview:

KDM4B or lysine (K)-specific demethylase 4B, which is also known as JMJD2B, contains a JmjN domain, a JmjC domain, a JD2H domain, 2 TUDOR domains, and a bipartite nuclear localization signal that overlaps the C-terminal part of the second TUDOR domain. KDM4B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6 (1). KDM4B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development (2). KDM4B is regulated by both ER and HIF-1, drives breast cancer cell proliferation in normoxia and hypoxia, and epigenetically regulates the expression of cell cycle genes such as CCND1, CCNA1, and WEE1.


Gene Aliases:

Jmjd2b; mKIAA0876; 4732474L06Rik


Genbank Number:


References:


1. Toyokawa G. et.al: The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6. 2011 Dec.

2. Kawazu M. et.al: Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development, 2011 Mar 18.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~125 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


RELATED PRODUCTS


  KDM1A Protein, K421-31G

  KDM4A Protein, K424-31G

  KDM5C Protein, K425-31CG

  KDM2A Protein, K422-31G


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