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KDM5B Protein

Recombinant mouse KDM5B (1-753) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K425-31BG


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Catalog No. Pack Size Price (USD)
K425-31BG-20 20 ug $215
K425-31BG-50 50 ug $435
K425-31BG-BULK BULK Contact Us  


Overview:

KDM5B is a lysine (K)-specific demethylase 5B which is highly expressed in testis and shows the lowest expression in skeletal muscle (1). KDM5B is a histone H3 lysine 4 (H3K4) demethylase up-regulated in prostate cancer and associated with androgen receptor where it regulated its transcriptional activity in reporter gene assays (2). Overexpression of KDM5B in HeLa cells results in loss of tri-, di-, and monomethyl H3K4, but does not alter the methylation status of H3K9 or H3K36. A KDM5B containing highly conserved putative DNA/chromatin binding motif is specifically up-regulated in breast cancer.


Gene Aliases:

Jarid1b;PUT1;Plu1;PLU-1;Rb-Bp2; AW556288; RBBP2H1A; mKIAA4034


Genbank Number:


References:


1. Kashuba, V. et.al: Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A). Europ. J. Hum. Genet. 8: 407-413, 2000.

2. Xiang, Y. et.al: JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc. Nat. Acad. Sci. 104: 19226-19231, 2007.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~112 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


RELATED PRODUCTS


  KDM4B Protein, K424-31BG

  KDM1A Protein, K421-31G

  KDM4A Protein, K424-31G

  KDM5C Protein, K425-31CG


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