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SIRT4 Protein

Full-length recombinant human SIRT4 was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. S38-30EG


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Catalog No. Pack Size Price (USD)
S38-30EG-50 50 ug $435
S38-30EG-20 20 ug $215
S38-30EG-BULK BULK Contact Us  


Overview:

SIRT4 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT4 being a member of class IV. SIRT4 lacks deacetylase activity but has ADP-ribosyltransferase activity (1). Immunoprecipitation analysis shows that SIRT4 interacts with the mitochondrial enzyme glutamate dehydrogenase (GDH), and functional analysis show that SIRT4 ADP-ribosylates and inhibits GDH (2). Downregulation of SIRT4 by RNA interference activates GDH, thereby upregulating insulin secretion in response to glucose and amino acids.


Gene Aliases:

SIR2L4, MGC57437, MGC130046, MGC130047, sirtuin 4


Genbank Number:


References:


1. Frye, R. A. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem. Biophys. Res. Commun. 260: 273-279, 1999.

2. Haigis, M. C. et al: SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126: 941-954, 2006.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~62 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


RELATED PRODUCTS


  SIRT5 Protein, S39-30EG

  SIRT6 Protein, S40-30EG

  SIRT7, Active, S41-30H

  SIRT3, Active, S37-38G


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