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SIRT3 Protein

Full-length recombinant human SIRT3 was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. S37-30EG


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Catalog No. Pack Size Price (USD)
S37-30EG-50 50 ug $435
S37-30EG-20 20 ug $215
S37-30EG-BULK BULK Contact Us  


Overview:

SIRT3 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT3 being a member of class I. SIRT3 contains an N-terminal mitochondrial targeting signal and a central catalytic domain and localizes in the nuclei and mitochondria (1). SIRT3 has NAD(+)-dependent histone deacetylase activity with specificity for lys16 of H4 and, to a lesser extent, lys9 of H3. SIRT3 can repress transcription of a target gene in vivo when recruited to its promoter. Full-length SIRT3 is transported from the nucleus to the mitochondria during cell stress conditions (2).


Gene Aliases:

SIR2L3, Sirtuin 3


Genbank Number:


References:


1. Onyango, P. et al: SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc. Nat. Acad. Sci. 99: 13653-13658, 2002.

2. Scher, M. B. et al: SirT3 is a nuclear NAD(+)-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev. 21: 920-928, 2007.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~66 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


RELATED PRODUCTS


  SIRT1 Protein, S35-31EG

  SIRT2, Active, S36-30H

  SIRT4 Protein, S38-30EG

  SIRT7, Active, S41-30H


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