KDM2B is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box proteins which constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination (1). KDM2B functions in a DNA repair process other than mismatch repair. KDM2B is highly expressed in aggressive brain tumors, which play a main role in cancer development (2). KDM2B is a key regulator of JUN function.
FBXL10, CXXC2, Fbl10, JHDM1B, PCCX2
1.Frescas, D. et.al: JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature 450: 309-313, 2007.
2.Jin, J. et al: Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 18: 2573-2580, 2004.
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Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Cell Cycle, Inflammation