Recombinant full-length human UBA3 (UBE1C) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. U203-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| U203-30G-20 | 20 ug | $215 | |
| U203-30G-50 | 50 ug | $435 | |
| U203-30G-BULK | BULK | Contact Us |
Overview:
UBA3 (also known as UBE1C) or ubiquitin-like modifier activating enzyme 3 is a member of the E1 ubiquitin-activating enzyme family. UBA3 associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. The mechanism of NEDD8 activation by APPBP1-UBA3 shows a high degree of conservation with ubiquitin activation by UBA1 (1). The NEDD8-activating enzyme, or NAE, composed of NAE1 and UBA3 subunits, is an essential component for the treatment of cancer disease (2).
Gene Aliases:
UBE1C, UBA3, hUBA3
Genbank Number:
References:
1. Bohnsack, R. N. et.al: Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. J. Biol. Chem. 278: 26823-26830, 2003.
2. Soucy, T. A. et.al: An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 458: 732-736, 2009.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~73 kDa
There are no related publications available for this product.
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