STAT2 (Signal transducer and activator of transcription) is a family member of STAT transcription factors that are implicated in programming gene expression in biological events as diverse as embryonic development, programmed cell death, organogenesis, innate immunity, adaptive immunity and cell growth regulation (1). JAKs can phosphorylate and activate STATs. Activation of the JAK/STAT pathway in response to cytokine action can lead to regulation of gene expression during proliferation and differentiation of the immune cells. STATs have been shown to be involved in inflammation, autoimmune and allergic diseases (2).
STAT113, ISGF-3, MGC59816, P113
1. Horvath, C.M.: STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci. 2000 Oct;25(10):496-502.
2. Pfitzner, E. et al: The role of STATs in inflammation and inflammatory diseases. Curr Pharm Des. 2004;10(23):2839-50.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway