Recombinant full-length human CyclinM was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C89-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C89-30G-20 | 20 ug | $215 | |
| C89-30G-50 | 50 ug | $435 | |
| C89-30G-BULK | BULK | Contact Us |
Overview:
Cyclin M, the only conventional cyclin partner of CDK10, protects CDK10 from ubiquitin-mediated degradation (1). Cyclin M exhibits strong sequence homology to transcriptional cyclins, especially the L-type cyclins that are associated with CDK11, 12 and 13 to regulate transcription and splicing (2). CDK10 is required to form a complex with Cyclin M in order to phosphorylate Histone H1, the canonical CDK substrate, and ETS2, a transcription factor that plays key roles in cancer and development (2).
Genbank Number:
References:
1. Khanal, P. et al: Proyl isomerase P1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells. Oncogene. 2012, 31:3845-56.
2. Guen, V.J. et al. The awakening of the CDK10/Cyclin M protein kinase. Oncotarget. 2017, 8(30):50174-50186.
Alternative Name(s):
CCNQ, CycM ; FAM58A
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Molecular Weight:
Observed MW ~54 kDa. Calculated MW ~54 kDa.
There are no related publications available for this product.
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