Overview:

UHMK1(KIS) or U2AF homology motif (UHM) kinase 1 is a serine/threonine protein kinase that promotes cell cycle progression through G1 phase. UHMK1 phosphorylates the cyclin-dependent kinase inhibitor 1B (p27Kip1) and this results in its export to the nucleus where it undergoes degradation. UHMK1 is a growth factor-dependent nuclear kinase which can regulate cell cycle progression (1). Elevated levels of UHMK1 protein in leukemia cells has been shown to promote cell cycle progression. UHMK1 has also been shown to function in the adult nervous system where it is highly expressed and the gene has been associated with schizophrenia (2).

Gene Aliases:

UHMK1; KIS; KIST

Genbank Number:

NM_144624

References:

1. Boehm. et.al: A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. EMBO J. 21: 3390-3401, 2002.

2. Bieche. et.al: Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human. Molec. Brain Res. 114: 55-64, 2003.