Overview:

WNK1 is a member of the WNK subfamily of serine/threonine protein kinases that is a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in WNK1 have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. WNK1 is a regulator of blood pressure and deficiency of this protein in mice lowers the blood pressure (1). WNK1 can regulate the Ca(2+) sensing and the subsequent Ca(2+)-dependent interactions mediated by synaptotagmin C2 domains and WNK1 exhibits additive CFTR inhibition (2).

Gene Aliases:

HSAN2; HSN2; KDP; KIAA0344; MGC163339; MGC163341; p65; PRKWNK1; PSK

Genbank Number:

NM_018979

References:

1. Zambrowicz, B. P. et.al: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc. Nat. Acad. Sci. 100: 14109-14114, 2003.

2. Lee, B.-H. et.al: WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Molec. Cell 15: 741-751, 2004.