FAK, Active
Recombinant full-length human FAK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P91-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P91-10G-05 | 5 ug | $226 | |
| P91-10G-10 | 10 ug | $325 | |
| P91-10G-BULK | BULK | Contact Us |
Recombinant full-length human FAK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P91-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P91-10G-05 | 5 ug | $226 | |
| P91-10G-10 | 10 ug | $325 | |
| P91-10G-BULK | BULK | Contact Us |
Overview:
FAK (Focal Adhesion Kinase) is a non-receptor protein tyrosine kinase involved in signal transduction from integrin-enriched focal adhesion sites that mediate cell contact with the extracellular matrix. FAK-enhanced signals have been shown to mediate the survival of anchorage-dependent cells and are critical for efficient cell migration in response to growth factor receptor and integrin stimulation (1). Elevated expression of FAK in human tumors has been correlated with increased malignancy and invasiveness (2). Elevated FAK expression in anaplastic astrocytoma and glioblastoma tumor biopsy samples has been demonstrated.
Gene Aliases:
PTK2; FADK; FAK1; FRNK; pp125FAK
Genbank Number:
References:
1. Schaller, M D.: Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim Biophys Acta. 2001 Jul 25;1540(1):1-21.
2. Gabarra-Niecko, V. et al: FAK regulates biological processes important for the pathogenesis of cancer. Cancer Metastasis Rev. 2003 Dec;22(4):359-74.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~140 kDa
Gao Chenxi et al., FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β Elife August 2015 10.7554/eLife.10072
Huang Yongqi et al., The Activity and Stability of the Intrinsically Disordered Cip/Kip Protein Family AreRegulated by Non-Receptor Tyrosine Kinases Journal of Molecular Biology January 2015 10.1016/j.jmb.2014.11.011
Lopez-Sancheza Inmaculada et al., Focal Adhesions are Foci for Tyrosine-Based Signal Transduction via GIV/Girdin and G proteins Molecular Biology of the Cell September 2015 10.1091/mbc.E15-07-0496
Tzenaki Niki et al., Focal adhesion kinase phosphorylates the phosphatase and tensin homolog deleted on chromosome 10 under the control of p110δ phosphoinositide-3 kinase FASEB Journal August 2015 10.1096/fj.15-274589
Huanga Zhi et al., JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin Cellular Signalling November 2008 10.1016/j.cellsig.2008.07.014
Lia Feng et al., Screening of epidermal growth factor receptor inhibitors in natural products by capillary electrophoresis combined with high performance liquid chromatography-tandem mass spectrometry Journal of Chromatography A June 2015 10.1016/j.chroma.2015.04.055
et al., ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain Pharmacology Research & Perspectives March 2021
AKT/PKB Pathway, Angiogenesis, Cancer, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Invasion/Metastasis
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