Overview:

TSSK1B (testis-specific serine kinase 1B) is a member of a unique subfamily of protein kinases belonging to the AMPK branch on the human kinome tree. TSSK1B is a serine/threonine kinases that is highly expressed in testis and lower express in pancreas, and weak expression in a few other tissues. TSSK members are present in the equatorial segment of human sperm. TSSK1B share 72% amino acid identity and 83% identity in the kinase domain with other family TSSK members and the TSSK1 gene is intronless. In vitro kinase assay shows phosphorylation of TSKS by TSSK1 and TSSK2.

Gene Aliases:

TSSK1, STK22D, FKSG81, SPOGA4

Genbank Number:

NM_032028

References:

1. Hao, Z. et.al: Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues: a TSSK member is present in the equatorial segment of human sperm.

2. Xu, B. et al: Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets. Soc Reprod Fertil Suppl. 2007;63:87-101.