Overview:

TTK is a serine/threonine kinase that has been implicated in the regulation of centrosome duplication and mitotic checkpoint response. Overexpressing of dominant-negative TTK in human cell lines prevents centrosome duplication while active TTK accelerates centrosome reduplication in an osteosarcoma cell line. Disruption of TTK function leads to a combination of severe mitotic abnormalities and failure in centrosome duplication (1). TTK is required for stabilization and activation of p53 during spindle disruption. TTK phoshorylates the N-terminal domain of p53 at Thr18, and this phosphorylation disrupts the interaction with MDM2 and abrogates MDM2-mediated p53 ubiquitination (2).

Gene Aliases:

ESK, PYT, MPS1, MPS1L1, FLJ38280

Genbank Number:

NM_003318

References:

1.Fisk H A, et al: Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression. Proc. Nat. Acad. Sci. 100: 14875-14880, 2003.

2.Huang Y F, et al: TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18. Mol Cell Biol. 2009 Jun;29(11):2935-44.