Overview:

Cyclin-G-associated kinase (GAK) is a serine/threonine protein kinase and was originally identified as a protein that is associated with cyclin G. However, neither CDK5 nor GAK kinase activity is activated by cyclin G nor does GAK affect CDK5 kinase activity. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.

Gene Aliases:

DNAJ26; DNAJC26

Genbank Number:

NM_005255

References:

1. Kanaoka Y, et al. GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain. FEBS Lett. 402(1):73-80, 1997.

2. Greener T, et al. Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Biol Chem. 275(2):1365-70, 2000