Overview:

CHK1 is a 56 kDa serine/threonine protein kinase that was originally identified in fission yeast to play a role in activation of the DNA damage checkpoint in the G2 phase of the cell cycle (1). CHK1 appears to function downstream of several of the known fission yeast checkpoint gene products, including that encoded by rad3+, a gene with sequence similarity to the ATM gene mutated in patients with ataxia telangiectasia (2).

Gene Aliases:

CHEK1

Genbank Number:

NM_001274

References:

1. Walworth, N. et al: Fission yeast CHK1 protein kinase links the rad checkpoint pathway to cdc2. Nature. 1993 May 27;363(6427):368-71.

2. Walworth, NC. et al: Rad-dependent response of the CHK1-encoded protein kinase at the DNA damage checkpoint. Science. 1996 Jan 19;271(5247):353-6.