Recombinant human JAK3 (JH2 domain) (551-790) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. J03-35G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
J03-35G-05 | 5 ug | $226 | |
J03-35G-10 | 10 ug | $325 | |
J03-35G-BULK | BULK | Contact Us |
Overview:
JAK3 is a member of the JAK family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. Low levels of JAK3 expression is detected in immature hematopoietic cells, which dramatically increases during terminal differentiation of these cells suggesting a role of JAK3 in the differentiation of hematopoietic cells. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease) (1). Mice lacking JAK3 show a severe block in B-cell development at the pre-B stage in bone marrow suggesting that JAK3 is critical for the progression of B-cell development in the bone marrow (2).
Gene Aliases:
JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN
Genbank Number:
References:
1. Russell S M, et al: Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 270: 797-799, 1995. 2. Thomis D C, et al: Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270: 794-797, 1995.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Approx. MW 58kDa
There are no related publications available for this product.
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