Overview:

RIPK5 is a dual specificity serine/threonine and tyrosine protein kinase that is a member of the RIPK family. RIPK5 is widely expressed in vertebrates with broad distributed in the central nervous system, and deregulated in certain human cancers (1). RIPK5 has been shown to function as a regulator of cell death. Overexpression of RIPK5 leads to cell death as evidenced by DNA fragmentation (2). RIPK5 induces both caspase-dependent and caspase-independent cell death, and N- and C-terminal RIPK5 deletion mutants retained the ability to induce cell death.

Gene Aliases:

DSTYK; DustyPK; HDCMD38P; KIAA0472; RIP5

Genbank Number:

NM_015375

References:

1.Peng, J. et al: Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain. Biochim Biophys Acta. 2006 Nov-Dec;1759(11-12):562-72..

2.Zha, J. et al: RIP5 is a RIP-homologous inducer of cell death. Biochem. Biophys. Res. Commun. 319: 298-303, 2004.