Bcr-Abl and Multikinase Inhibitor
Catalog No. A03-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A03-900-05 | 5 mg | $66 | |
| A03-900-25 | 25 mg | $270 | |
| A03-900-BULK | BULK | Contact Us |
Overview:
Highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM) (1). Also inhibits PDGFRα, c-SRC and c-KIT (IC50=1.1, 5.4 and 12.5 nM respectively) (2) as well as FGFR-mediated signaling (IC50<40 nM) (3). Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models (4).
References:
1. T O’Hare et al. Cancer Cell 2009 16:401. 2. JM Gozgit et al. Mol. Cancer Ther. 2011 10:1028. 3. JM Gozgit et al. Mol. Cancer Ther. 2012 11:690. 4. S Chen et al. Front Immunol. 2019 10:1393.
CAS Registry Number:
943319-70-8
Molecular Formula:
C29H27F3N6O
Appearance:
Yellow powder
Solubility:
May be dissolved in DMSO (50 mg/ml); or ethanol (25 mg/ml, warm)
Molecular weight:
532.6
Purity:
>98% (HPLC); NMR (Conforms)
Melting point:
N/A
Storage and Stability:
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
Molecular structure:
|
Aliases:
3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide; AP-24534
There are no related publications available for this product.
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