Catalog No. P312-905
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Nitazoxanide is a broad-spectrum synthetic benzamide compound that is used as medicine for the treatment of various helminthic, protozoal, and viral infections. In-vitro analysis suggests that this compound inhibits replication of many members of the coronavirus family including MERS-Cov, BCoV, HECoV, and improves clinical outcomes by suppressing the overproduction of pro-inflammatory cytokines which is observed in patients with coronavirus infection. The clinical implications of this compound on SARS-CoV-2 is under investigation at the moment. **
Nitazoxanide is a clinically useful antiparasitic agent (1). It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, hepatitis B and C, RSV, coronavirus, dengue, and others (2). Its antiparasitic activity is believed to be due to inhibition of pyruvate:ferredoxin/flavodoxin oxidoreductases (3). Antiviral activity involves activation of protein kinase activated by double-stranded RNA (PKR) leading to phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) (4). Nitazoxanide has also been found to inhibit Wnt signaling independent of adenomatous polyposis coli (APC), targeting peptidyl arginine deiminase 2 (PAD2) resulting in increased citrullination of β-catenin (5).
1. CA White Expert Rev. Anti. Infect. Ther. 2004 2:43
2. J-F Rossignol Antiviral Res. 2014 110:94
3. PS Hoffman et al. Antimicrob. Agents Chemother. 2007 51:868
4. M Elazar et al. Gastroenterology 2009 137:1827
5. Y Qu et al. Nat. Chem. Biol. 2018 14:94
CAS Registry Number:
>98% (HPLC); NMR (conforms)
May be dissolved in DMSO (50 mg/ml)
O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate; NTZ
Storage and Stability:
Store desiccated as supplied -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.
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