Overview:

**COVID-19 RELATION**
Niclosamide is an active chlorinated salicylanilide compound, with anthelmintic and potential antineoplastic activity used to treat tapeworm infections but has a broad spectrum of therapeutic potential. Scientists are investigating niclosamide and how it inhibits CoV replication and viral antigen synthesis by investigating the various mode of actions such as regulating the mTORC1 pathway, members of which may be interacting with SARS-CoV-2 N and Orf8 proteins; and reducing replication of related coronavirus MERS-CoV via SKP2 inhibition.**

Reversibly inhibits Mtorc1 signaling and stimulates autophagy (1). Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Inhibits transcription of STAT3 target genes and induces cell cycle arrest and apoptosis in cells with constitutively active STAT3 (2). Reverses radioresistance in human lung cancer cells and xenografts (3).

References:

1. AD Balgi et al. PloS One 2009 4:e7124

2. X Ren et al. ACS Med. Chem. Lett. 2010 1:454

3. Y Shuo et al. Mol. Cancer Ther. 2013 13:606