Catalog No. I23-905
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Mycophenolic acid (MPA), an immunosuppressant, is an uncompetitive and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). The immunomodulator has been actively studied for its in vitro antiviral potency against a broad family of viruses including seasonal influenza and MERS and has shown a positive effect on improving the state of patients suffering from severe pneumonia caused by these viruses. As a potent IMPDH inhibitor, scientists are studying its antiviral role against the SARS-COV-2 virus, as studies suggest that the novel virus interacts with cellular IMPDH2 utilizing the Nsp14 viral protein.**
Immunomodulator (1). Blocks the biosynthesis of guanine nucleotides via inhibition of inosine 5’-monophosphate dehydrogenase which suppresses the production of proinflammatory cytokines, nitric oxide and LDH in macrophages (2,3). Inhibits IL-2-dependent T cell proliferation (4).
1. EM Eugui et al. Scand. J. Immunol. 1991 33:161
2. CA Jonsson et al. Cell. Immunol. 2002 216:93
3. AC Allison et al. Ann. NY Acad. Sci. 1993 696:63
4. J Quemeneur et al. J. Immunol. 2002 169:2747
CAS Registry Number:
>98% (HPLC); NMR (conforms)
May be dissolved DMSO (30 mg/ml); or ethanol (30 mg/ml).
6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexanoic acid; NSC129185
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.
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