Catalog No. A51-906
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Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). The compound is an effective treatment against high blood pressure and a few types of congestive heart failures. SARS-CoV-2 infects the human cells by using its Spike (S) protein to fuse with the human ACE2 cell receptor. Renin-Angiotensin-Aldosterone System Inhibitors such as Captopril are being investigated for their unconventional therapeutic role in inhibiting SARS-CoV-2/ACE2 fusions as a possible treatment option to solve the COVID-19 crisis.**
Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.22 μM) (1). Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and competitively (Ki = 6.0 &muM for leukotriene B4 formation and Ki = 60 nM for L-lysine-p=nitroanilide) (2). Displays vasodilatory and antihypertensive effects in vivo. Clinically useful antihypertensive agent.
1. DW Cushman et al. Nat. Med. 1999 5:11102.
2. L Orning et al. J. Biol. Chem. 1991 266:16507
CAS Registry Number:
>98% (HPLC, TLC); NMR (conforms)
May be dissolved in DMSO (20 mg/ml) or water (20 mg/ml)
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.
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