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Captopril

ACE Inhibitor
Catalog No. A51-906


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Catalog No. Pack Size Price (USD)
A51-906-1 1 g $45
A51-906-05 5 g $145
A51-906-BULK BULK Contact Us  


Overview:

**COVID-19 RELATION**
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). The compound is an effective treatment against high blood pressure and a few types of congestive heart failures. SARS-CoV-2 infects the human cells by using its Spike (S) protein to fuse with the human ACE2 cell receptor. Renin-Angiotensin-Aldosterone System Inhibitors such as Captopril are being investigated for their unconventional therapeutic role in inhibiting SARS-CoV-2/ACE2 fusions as a possible treatment option to solve the COVID-19 crisis.**

Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.22 μM) (1). Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and competitively (Ki = 6.0 &muM for leukotriene B4 formation and Ki = 60 nM for L-lysine-p=nitroanilide) (2). Displays vasodilatory and antihypertensive effects in vivo. Clinically useful antihypertensive agent.

References:


1. DW Cushman et al. Nat. Med. 1999 5:11102.

2. L Orning et al. J. Biol. Chem. 1991 266:16507


CAS Registry Number:

62571-86-2


Molecular Formula:

C9H15NO3S


Appearance:

White powder


Molecular Weight:

217.3


Purity:

>98% (HPLC, TLC); NMR (conforms)


Solubility:

May be dissolved in DMSO (20 mg/ml) or water (20 mg/ml)


Aliases:

(2S)-1-(3-mercapto-2-methyl-propionyl)-L-proline


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


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