Recombinant mouse ALK2 (R206H) (147-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A06M-12BG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
A06M-12BG-05 | 5 ug | $226 | |
A06M-12BG-10 | 10 ug | $325 | |
A06M-12BG-BULK | BULK | Contact Us |
Overview:
ALK 2 is a receptor serine/threonine kinase that is member of the ALK family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ALK2, but not TGFβRI (ALK5), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ALK2 is sufficient to restore a low-motility phenotype in endoglin deficient cells (1). Therefore, endoglin decreases prostate cancer cell motility through activation of the ALK2-Smad1 pathway. ALK2 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues (2).
Genbank Number:
References:
1. Craft, C.S. et al: Endoglin inhibits prostate cancer motility via activation of the ALK2-Smad1 pathway. Oncogene. 2007 Nov 8;26(51):7240-50.
2. Shore, E. M. et al: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nature Genet. 38: 525-527, 2006
Alternative Name(s):
Acvr1, Acvrlk2, Tgfb1
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet
Molecular weight:
Observed MW ~67 kDa. Calculated MW ~67.2 kDa.
There are no related publications available for this product.
Cancer, Cell Cycle, Cellular Stress
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