Specific Activity:

Sample activity data. For lot specific data, please refer to the respective datasheet.

Purity:

Sample purity data. For lot specific data, please refer to the respective datasheet.

Alternative name(s):

2019-nCoV s1, SARS-CoV-2 spike S1, SARS-CoV-2 S1, novel coronavirus spike s1, nCov spike s1, coronavirus spike S1. The UniProt accession number is P0DTC2.

Storage and Stability:

Aliquot product into smaller quantities after centrifugation and store at –70oC. For best performance, avoid repeated handling and multiple freeze/thaw cycles.

Scientific Background :

Novel coronavirus SARS-CoV-2 has caused the pandemic of respiratory diseases (COVID-19) around the world since 2020 (1). The spike glycoprotein (S) of coronavirus, a type I transmembrane protein containing two subunits, S1 and S2 is known to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2) and facilitate viral entry into the host cell (2). The highly transmissible B.1.617 variant identified in India has mutations (L452R, E484Q, D614G, P681R) in the spike protein. These mutations may result in increased transmissibility and re-infection or resistance to vaccine-elicited antibody. As new variants emerge, it is pivotal to evaluate their transmissibility, virulence, and their possible tendency to escape antibody neutralization (3).

Molecular Weight:

approx. MW ~120 kDa calc. MW 76.4 kDa